RiteMED Levofloxacin Caution For Usage

Directions for Use, Compatibility and Stability: No further dilution of levofloxacin solution for infusion is necessary.
Prior to administration, parenteral drug products should be inspected visually for particulate matter and discoloration whenever solution and container permit.
Observe strict aseptic technique when inserting the cannula of the infusion set into the spout of levofloxacin solution for infusion. If contaminated, it has the potential to become a source of infection to patients. The cannula of the infusion set should be inserted fully and not halfway into the spout of the levofloxacin solution for infusion container to avoid leakage.
Since only limited data are available on the compatibility of levofloxacin solution for infusion with other IV substances, additives or other medications should not be added to levofloxacin IV or infused simultaneously through the same IV line. If the same IV line is used for sequential infusion of several different drugs, the line should be flushed before and after infusion of levofloxacin IV with an infusion solution compatible with levofloxacin IV and with any other drugs administered via this common line.
Levofloxacin solution for infusion should not be co-administered with any solution containing multivalent cations, e.g., magnesium, through the same IV line.
Levofloxacin 250 mg/50 mL and 500 mg/100 mL solution for infusion is compatible with 0.9% Sodium Chloride Solution, 5% Dextrose Injection, 2.5% Dextrose in Ringer's Solution, and combination solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes).
Levofloxacin 750 mg/150 mL solution for infusion should not be mixed with heparin or alkaline solution (e.g., sodium bicarbonate, etc.). It should be used within 3 hours after rubber stopper opening in order to prevent bacterial contamination.
Levofloxacin solution for infusion is for single-use only; any unused portion should be discarded properly.